In a large mixing bowl, combine the ground beef with salt, pepper, garlic powder, and onion powder. Mix well until the seasonings are evenly distributed.

Divide the seasoned beef into 8 equal portions and shape each into a small patty. Make a slight indentation in the center of each patty to ensure even cooking.

Heat a large skillet over medium-high heat. Cook the patties for about 3 minutes on each side, or until they reach your desired level of doneness.

Place a slice of cheddar cheese on top of each patty during the last minute of cooking. Cover the skillet with a lid to help the cheese melt.

While the patties are cooking, slice the slider buns in half and lightly toast them on the stove or in the oven until golden brown.

Place each cooked patty on the bottom half of a toasted bun. Add lettuce, tomato slices, and pickles. Spread ketchup and mustard on the top bun and place it over the toppings.

Serve the sliders immediately while they are warm and the cheese is gooey. Pair them with your favorite sides for a complete meal.

To store leftovers, wrap each slider individually in foil or parchment paper and refrigerate for up to 3 days. Reheat in the oven at 300°F for about 10 minutes before serving.